Senior Lead Manager Quality Assurance Searle Company Limited Karachi

Are you an experienced Quality Assurance professional in the pharmaceutical industry looking for a leadership opportunity in Karachi? Searle Company Limited has announced a career opportunity for the position of Lead/Senior Lead Manager Quality Assurance at its Karachi Plant (SITE). This is an excellent opportunity for qualified pharmaceutical and chemistry professionals who have strong experience in quality assurance, GMP compliance, validation, deviations, CAPA, OOS/OOT investigations, and regulatory audits.

The position is aimed at professionals with 10–12 years of relevant experience who can take ownership of critical quality functions and lead teams in a highly regulated pharmaceutical manufacturing environment.

If you have a Pharm-D or M.Sc. in Chemistry, strong managerial abilities, and extensive experience in pharmaceutical quality systems, this opportunity may be worth considering.

Searle Lead/Senior Lead Manager QA Jobs 2026 – Overview

The Lead/Senior Lead Manager Quality Assurance will play a key role in ensuring that manufacturing and packaging operations meet established quality standards and comply with approved procedures and regulatory expectations.

The successful candidate will be responsible for overseeing various QA activities, including in-process control (IPC), manufacturing and packaging compliance, deviation investigations, CAPA management, toll manufacturing quality, validation systems, and audit readiness.

This is a senior-level position that requires both technical expertise and strong leadership skills. The selected professional will also collaborate with Production and other departments to maintain effective quality systems throughout the manufacturing operation.

Job Details

About the Lead/Senior Lead Manager Quality Assurance Role

Quality Assurance is one of the most important functions in pharmaceutical manufacturing because medicines and healthcare products must consistently meet strict quality, safety, efficacy, and regulatory requirements.

As a Lead/Senior Lead Manager QA, the selected candidate will be expected to provide leadership across important quality systems at the Karachi Plant. The role involves working closely with manufacturing teams while ensuring that processes are performed according to approved SOPs, current Good Manufacturing Practices (cGMP), and applicable regulatory requirements.

The position is therefore suitable for someone who understands pharmaceutical manufacturing processes and can identify potential quality risks before they affect products or operations.

Key Responsibilities

1. Ensure Manufacturing and Packaging Compliance

One of the major responsibilities will be ensuring that manufacturing, packaging, and in-process control activities are conducted according to approved procedures.

The successful candidate will:

• Monitor compliance with approved SOPs.
• Ensure adherence to cGMP requirements.
• Review quality practices associated with manufacturing and packaging.
• Ensure appropriate in-process controls (IPC) are implemented.
• Identify quality gaps and recommend corrective actions.
• Work with relevant departments to maintain consistent quality standards.

Strong knowledge of pharmaceutical manufacturing processes will be important for successfully performing these responsibilities.

2. Manage In-Process Control Operations

The position also involves managing IPC operations and ensuring that quality activities are properly planned and documented.

Responsibilities may include:

• Planning IPC staff requirements.
• Supervising and supporting IPC teams.
• Ensuring employees receive appropriate training.
• Maintaining timely and accurate documentation.
• Coordinating IPC activities with Production and other departments.
• Ensuring in-process quality checks are performed according to established procedures.

Effective coordination is particularly important because QA teams need to work closely with manufacturing operations without compromising quality requirements.

3. Investigate Deviations, OOS and OOT Results

A senior QA professional must be capable of handling unexpected quality events and determining their underlying causes.

The selected candidate will be responsible for supporting and leading investigations related to:

• Deviations
• Out-of-Specification (OOS) results
• Out-of-Trend (OOT) results
• Quality-related incidents and process gaps

The candidate will need to ensure that investigations are properly documented and that appropriate corrective and preventive actions are established.

CAPA Management

An important part of the position is implementing and following up on CAPA — Corrective and Preventive Action.

The successful candidate will help ensure that:

• Root causes are appropriately identified.
• Corrective actions are practical and effective.
• Preventive measures address recurring risks.
• Quality actions are completed within required timelines.
• CAPA effectiveness is appropriately monitored.
• Open quality actions are followed up until closure.

Strong analytical and problem-solving skills will therefore be valuable for this position.

4. Lead Toll Manufacturing Quality Activities

Searle is also seeking a professional capable of managing quality-related activities associated with toll manufacturing partners.

This responsibility includes ensuring that external manufacturing partners maintain agreed quality and GMP standards.

The role may involve:

• Supporting and conducting partner audits.
• Reviewing manufacturing and quality documentation.
• Ensuring GMP compliance.
• Checking compliance with agreed product specifications.
• Coordinating quality requirements with manufacturing partners.
• Supporting technical and commercial agreements from a quality perspective.
• Following up on observations and corrective actions.

Experience dealing with external manufacturing partners can be particularly useful for candidates applying for this senior QA position.

5. Compliance Meetings and Audit Follow-Up

The selected professional will participate in and lead compliance meetings related to quality systems and manufacturing activities.

Another important responsibility will be responding to audit observations and ensuring that identified gaps are addressed effectively.

The candidate will be expected to:

• Identify compliance gaps.
• Discuss quality observations with relevant stakeholders.
• Develop appropriate corrective actions.
• Monitor CAPA progress.
• Ensure timely closure of audit-related actions.
• Maintain a strong state of audit and inspection readiness.

The ability to communicate quality concerns clearly to different departments is essential for this responsibility.

6. Develop and Maintain the Validation Master Plan

A major component of this role is responsibility for the company’s Validation Master Plan (VMP).

The successful candidate will lead the development, implementation, maintenance, and continuous improvement of the company’s validation system.

This includes ensuring that:

• The Validation Master Plan remains current.
• Validation activities meet regulatory expectations.
• Validation systems remain inspection-ready.
• Required validation documentation is properly maintained.
• Validation activities are effectively coordinated.
• Regulatory audit requirements are addressed.

The selected candidate will also represent the Validation function during regulatory audits, making knowledge of pharmaceutical validation and regulatory expectations particularly important.

Required Qualification for Searle QA Jobs

Candidates interested in applying for the Lead/Senior Lead Manager Quality Assurance position should meet the educational and professional requirements specified by the company.

Educational Requirements

Applicants should have one of the following qualifications:

• Pharm-D
• M.Sc. in Chemistry

A relevant educational background is important because the position involves technical pharmaceutical quality systems, manufacturing compliance, validation, and regulatory requirements.

Experience Requirements

Searle requires candidates to have 10–12 years of relevant experience.

Because this is a senior leadership role, applicants should ideally have substantial experience in areas such as:

• Pharmaceutical Quality Assurance
• GMP compliance
• Manufacturing quality systems
• In-process controls
• Deviation management
• OOS/OOT investigations
• CAPA
• Validation
• Regulatory inspections
• Audits and compliance
• Pharmaceutical manufacturing operations

Candidates with extensive experience managing QA teams and coordinating with Production and other cross-functional departments may be particularly well suited to the position.

Skills Required

In addition to technical expertise, Searle highlights the importance of strong interpersonal and managerial capabilities.

Important skills include:

• Excellent interpersonal communication
• Strong managerial skills
• Leadership abilities
• Problem-solving and analytical thinking
• Quality risk awareness
• Team management
• Cross-functional coordination
• Audit management
• Regulatory compliance knowledge
• Decision-making abilities
• Effective documentation and reporting

Since the position involves leading teams and interacting with multiple departments, communication and leadership skills are just as important as technical knowledge.

Who Should Apply?

This vacancy is particularly suitable for experienced professionals who want to take their pharmaceutical QA career to the next level.

You may be a strong candidate if you:

• Hold a Pharm-D or M.Sc. in Chemistry.
• Have 10–12 years of relevant pharmaceutical experience.
• Have experience with GMP and SOP compliance.
• Understand deviation, OOS/OOT, and CAPA processes.
• Have experience managing or supporting validation activities.
• Can manage IPC operations and QA teams.
• Have participated in audits and regulatory inspections.
• Understand quality requirements for toll manufacturing.
• Possess strong communication and leadership skills.
• Can work effectively with Production and other business functions.

Why This Opportunity Is Important

A senior QA position in pharmaceutical manufacturing offers professionals the chance to influence quality systems at an organizational level. Rather than focusing only on individual testing or documentation tasks, the Lead/Senior Lead Manager QA is expected to provide leadership across broader quality processes.

The role combines technical pharmaceutical knowledge, regulatory compliance, team leadership, investigation management, validation, and continuous quality improvement.

For an experienced professional, it can therefore represent a significant step toward broader leadership responsibilities within the pharmaceutical sector.

How to Apply for Searle Lead/Senior Lead Manager QA Jobs

Interested and eligible candidates should prepare an updated CV/resume highlighting their relevant pharmaceutical QA experience, qualifications, leadership responsibilities, and technical expertise.

Applicants should send their resume to:

[email protected]

The application deadline is August 28, 2026.

Candidates should mention “Lead Manager QA” in the email subject line as instructed in the vacancy announcement.

Application Checklist

Before submitting your application, make sure your CV clearly includes:

• Pharm-D or M.Sc. in Chemistry
• Total years of relevant experience
• Pharmaceutical QA experience
• GMP and SOP compliance experience
• IPC management experience
• Deviation/OOS/OOT investigation experience
• CAPA experience
• Validation experience
• Audit and regulatory inspection exposure
• Leadership and team-management experience
• Relevant contact information

Using the required subject line can also help ensure your application is correctly identified during the recruitment process.

Final Thoughts

The Searle Lead/Senior Lead Manager Quality Assurance Jobs 2026 offer an important opportunity for experienced pharmaceutical professionals in Karachi. With responsibility for manufacturing and packaging compliance, IPC operations, deviations, OOS/OOT investigations, CAPA, toll manufacturing quality, audits, and validation, the role requires a well-rounded QA leader.

Candidates with 10–12 years of relevant experience, a Pharm-D or M.Sc. in Chemistry, and proven managerial and communication skills should consider applying before the August 28, 2026 deadline.

If your professional background aligns with the requirements, update your resume, highlight your strongest QA and leadership achievements, and submit your application to [email protected] with “Lead Manager QA” in the subject line.

Apply on time and make sure your CV demonstrates the specific pharmaceutical quality experience required for this senior-level opportunity.